Hello friends in this post we are going to discuss about Antiepileptic MCQ with answer | Antiepileptic Multiple choice questions | Antiepileptic Question answers dumps | Antiepileptic Objective type questions | Antiepileptic based questions
1. The mechanism of action of antiepileptic drugs is :
a) Enhancement of GABA-ergic (inhibitory) transmission
b) inhibition of excitatory (usually glutamate-ergic) transmission
c) Modification of ionic conductance
d) All of the above
Ans: d
2. which of the following has an impotent effect on the T-type calcium channels in thalamic neurons?
a) Carbamazepine
b) Lamotrigine
c) Ethosuximide
d) Phenytoin
Ans: c
3.The drug which does not produce a voltage-dependent inactivation of sodium channels is :
a) Lamotrigine
b) Carbamazepine
c) Phenytoin
d) Vigabatrine
Ans: d
4. The antiepileptic drug, which produce inhibition of the central effects of excitatory amino acids is :
a) Ethosuximide
b) Lamotrigine
c) Diazepam
d) Tiagabine
Ans: b
5. The drug which is not used for partial and generalized tonic-clonic seizures is :
a) Carbamazepine
b) Valproate
c) Phenytoin
d) Vigabatrine
Ans: d
6.The drug which is used for absence seizures is :
a) Sodium valproate
b) Phenobarbital
c) Carbamazepine
d) Phenytoin
Ans: a
7.The drug which is used for myoclonic seizures is:
a) Primidone
b) Carbamazepine
c) Clonazepam
d) Phenytoin
Ans: c
8.The most effective drug in status epilepticus in adults is :
a) Carbamazepine
b) Ethosuximide
c) Diazepam
d) Zonisamide
Ans: c
9.Regarding phenytoin:
a) It effects on Ca2+ currents, reducing the low-threshold (T-type) current
b) It blocks Na+ channels
c) It inhibits GABA-transaminase, which catalyzes the breakdown of GABA
d) None of the above .
Ans: b
10.Phenytoin is used in the treatment of:
a) Petit mal epilepsy
b) Grand mal epilepsy
c) Myoclonic seizures
d) None of the above
Ans: b
11.Dose-related adverse effect caused by phenytoin is:
a) Physical and psychological dependence
b) Gingival hyperplasia
c) Exacerbated grand mal epilepsy
d) Steven-Johnson syndrome .
Ans: b
12.Granulocytopenia , GI irritation and facial hirsutism are possible adverse effects of:
a) Phenobarbital
b) Ethosuximide
c) Phenytoin
d) Carbamazepine
Ans: c
13.which of the following does not induce hepatic microsomal enzymes ?
a) Carbamazepine
b) Phenytoin
c) Phenobarbital
d) Sodium valproate
Ans: d
14. The drug of choice for partial seizures is:
a) Carbamazepine
b) Diazepam
c) Ethosuximide
d) Phenytoin
Ans: a
15. The mechanism of action of Carbamazepine appears to be similar to that of:
a) Benzodiazepines
b) Sodium valproate
c) Phenytoin
d) Ethosuximide
Ans: c
16. Which of the following is also effective in treating trigeminal neuralgia?
a) Carbamazepine
b) Phenytoin
c) Vigabatrine
d) Lamotrigine
Ans: a
17.The most common adverse effects of Carbamazepine are:
a. Diplopia, ataxia, and nausea
b.Gingival hyperplasia, hirsutism
c.Sedation, physical and psychological dependence
d.All of the above
Ans: a
18. Phenobarbital causes :
a) Physical and phychological dependence
b) Exacerbated petit mal epilepsy
c) Sedation
d) All of the above
Ans: d
19.Lamotrigine can be used alone in the treatment of all the following except :
a) Partial seizures
b) Absence
c) Myoclonic seizures
d) Generalized tonic – clonic seizures .
Ans: d
20. The mechanism of action of vigabatrine is :
a) Direct action on the GABA receptor-chloride channel complex
b) Inhibition of GABA aminotransferase
c) NMDA receptor blockade via the glycine binding site
d) Inhibition of GABA neuronal reuptake from synapses
Ans: b
21.The mechanism of topiramates action is:
a) Reduction of excitatory glutamate-ergic neurotransmission
b) Inhibition of voltage sensitive Na+ channels
c) Potentiation of GABA-ergic neuronal transmission
d) All of the above
Ans: d
22.The drug of choice in the treatment of petit mal (absence seizures) is:
a) Phenytoin
b) Ethosuximide
c) Phenobarbital
d) Carbamazepine
Ans: b
23.adverse effects of ethosuximide are all the following except :
a) Gastric upset such as anorexia, pain, nausea and vomiting
b) Exacerbated grand mal epilepsy
c) Fatigue , Dizziness and headache
d) Aggressive behavior
Ans: d
24. Sodium valproate is very effective against all the following except :
a) Absence seizures
b) Myoclonic seizures
c) Generalized tonic-clonic seizures
d) Partial seizures .
Ans: d
25.The drug of choice in the treatment of myoclonic seizures is:
a) Sodium valproate
b) Phenobarbital
c) Phenytoin
d) Ethosuximide
Ans: a
26.Which of the following antiepileptic drugs may produce teratogenicity?
a) Phenytoin
b) Valproate
c) Topiramate
d) All of the above
Ans: d
27. The most dangerous effect of antiepileptic drugs after large overdoses is:
a) Respiratory depression
b) Gastrointestinal irritation
c) Alopecia
d) Sedation
Ans: a